HORMONE REPLACEMENT THERAPIES

DUPHASTON® (dydrogesterone)
Solvay Pharmaceuticals’ DUPHASTON® is one of the leading progestogens in Europe and market leader in a number of other countries. DUPHASTON® (dydrogesterone) is very similar to women’s natural progesterone. Due to its high selectivity and activity it has less side effects than all other progestogens including progesterone. DUPHASTON® is useful in a wide range of gynecological conditions caused by progesterone deficiency, such as endometriosis, premenstrual syndrome, and irregular or absent menstruation. As progesterone deficiency may also prevent a fertilized egg from implanting properly in the uterus wall, DUPHASTON® is also used by women struggling with infertility and habitual abortion. In the past years, a large number of studies proved the efficacy of DUPHASTON® in the protection of the endometrium of postmenopausal women on estrogen replacement therapy.

	generic name
	brandnames
	product description
	indications
	description of indications
	worldwide availability
	date and country of first launch
	average dosages
	links

generic name
dydrogesterone
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brandnames
DUPHASTON®, DUFASTON®, TEROLUT®, DABROSTON®, DYDROPAUSE®
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product description
DUPHASTON® (dydrogesterone) is a progestogen. It is very similar in structure to a woman’s natural progesterone.
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indications
Treatment of progesterone deficiencies:
Dysmenorrhea
Endometriosis
Secondary amenorrhea
Irregular cycles
Dysfunctional uterine bleeding
Pre-menstrual syndrome
Threatened and habitual abortion
Infertility due to luteal insufficiency
In combination with estrogens: Hormone replacement therapy [back to top]

description of indications
Progesterone deficiency
DUPHASTON® (dydrogesterone) is prescribed for women with progesterone deficiency. Progesterone is a hormone that a woman’s body produces after ovulation. It helps to form a lining in the uterus to allow a fertilized egg to implant in the uterus. If no implantation occurs, the production of progesterone is stopped and the uterus lining breaks down into menstruation. If the body does not make enough progesterone, this may lead to difficult and painful menstruation (dysmenorrhea), irregular bleeding (metrorrhagia), lack of bleeding (amenorrhea), heavy bleeding (menorrhagia) or premenstrual syndrome. Duphaston can also be used to treat patients with endometriosis. Endometriosis occurs when endometrial tissue, the tissue that lines the uterus and is shed during menstruation, grows outside of the uterus (on fallopian tubes, ovaries or anywhere else in the pelvic cavity). Because these areas build up and bleed during the menstrual cycle just as the uterus lining does, scar tissue is formed around them. This may lead to chronic pelvic pain, or even infertility.
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worldwide availability
DUPHASTON® (dydrogesterone) is available in more than 90 countries in Europe, Australia, and Asia.
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date and country of first launch
1961
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average dosages
DUPHASTON® tablets contain 10 mg dydrogesterone. The dosage and dosage regimen depend largely on the indication. For most indications 10 to 20 mg per day are administered on a sequential base, i.e. 14 to 21 days per cycle of 28 days. For hormone replacement therapy, DUPHASTON® can also be administered continuously.
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Links
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