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 TRICOR® (Lipanthyl®) is a very successful fenofibrate which was added to our portfolio after the acquisition of Fournier Pharma. Therapeutic doses of TRICOR® produces elevation of the ‘good’ HDL cholesterol, a reduction in the content of the ‘bad’ LDL cholesterol, and a substantial reduction in triglycerides (major component of fat tissue). The active ingredient in fenofibrate is fenofibric acid. Fenofibric acid inhibits the synthesis of cholesterol as well as enhancing its elimination as bile salts, while in addition both inhibiting the synthesis of triglycerides and enhancing their breakdown. In the US, where fenofibrate is co-promoted under the brand name TRICOR® with Abbott, the product has become a blockbuster.
Four classes of drugs are commonly used to lower cholesterol: statins, fibrates, bile acid sequestrants and nicotinic acid. Statins have the highest market share, but there is an increasing tendency for combination therapy because one drug is often not enough to lower cholesterol to normal levels and combinations allow treatment more specifically suited to individual patients’ needs. |
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